Understanding Arthritis: Causes, Symptoms, Diagnosis, and Treatment

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Arthritis is a broad term that covers a group of over 100 diseases. The word “arthritis” means “joint inflammation.” Inflammation is one of your body’s natural reactions to disease or injury. It includes swelling, pain, and stiffness. Inflammation that lasts a very long time or comes back, as in arthritis, can lead to tissue damage.

A joint is where two or more bones come together, such as the hip or knee.

The bones of your joints are covered with a smooth, spongy material called cartilage. It cushions the bones and allows the joint to move without pain.

The joint is lined by the synovium. The synovium’s lining produces a slippery fluid — called synovial fluid — that nourishes the joint and helps limit friction within.

Outside it is a strong fibrous casing called the joint capsule. Strong bands of tissue, called ligaments, connect the bones and help keep the joint stable. Muscles and tendons also support your joints and allow you to move.

With arthritis, an area in or around a joint becomes inflamed, causing pain, stiffness, and sometimes, difficulty moving. Some types of arthritis also affect other parts of the body, such as the skin and internal organs.

About 1 in 5 adults has some form of arthritis. It can happen to anyone, but it becomes more common as you age.

Some of the more common types of arthritis are:

Osteoarthritis. This is the most common type. It causes the cartilage on the ends of your bones to wear away. That makes the bones rub against each other. You might have pain in your fingers, knees, or hips.

The cartilage breakdown, or degeneration, of osteoarthritis often happens with age. This is why osteoarthritis is sometimes called degenerative joint disease. But if there are other causes, it can begin much sooner. For example, an athletic injury like a torn anterior cruciate ligament (ACL) or a fracture near a joint can lead to arthritis. It can happen in any joint but most often affects the hands and weight-bearing joints such as the knee, hip, and facet joints (in the spine).

Rheumatoid arthritis. This long-lasting disease can affect joints in any part of the body but most often involves the hands, wrists, and knees. With rheumatoid arthritis, the immune system — the body’s defense system against disease — mistakenly attacks the joints and causes the joint lining to swell. The inflammation spreads to the nearby tissues and can damage cartilage and bone. In more severe cases, rheumatoid arthritis can affect other areas of the body, such as the skin, eyes, and nerves.

Gout. This is a painful condition that happens when the body can’t get rid of a natural substance called uric acid. The excess uric acid forms needle-like crystals in the joints that cause marked inflammation with swelling and severe pain. Gout most often affects the big toe, knee, and wrist joints.

The cause of many types of arthritis is unknown. Researchers are looking into the role of genetics (heredity) and lifestyle in the development of arthritis.

There are several things that may raise your risk for arthritis, including:

Age. Over time, your joints tend to get worn down. That’s why the risk of developing arthritis, especially osteoarthritis, goes up with age.

Sex. Most types of arthritis are more common among women, except for gout.

Genes. Certain types of arthritis run in families. Conditions like rheumatoid arthritis, lupus, and ankylosing spondylitis, for example, are linked to certain genes.

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